Partners and Projects

ANIMAL MODELS

Rare diseases

Within the research project ZF-Health (Zebrafish Regulomics for Human Health), ZF BioLabs has generated two morphant zebrafish for two rare diseases associated withZF Health-logomitochondrial enzymes, Friedreich’s ataxia and Leigh Syndrome, and has performed a moderate-throughput screening of compounds to identify suppressors of disease phenotypes. http://www.zf-health.org/.

The project is being developed by a Pan-European research consortium formed by 19 different organizations and ZF Biolabs is the only Spanish organization within the consortium.

Laminophaties

Euro-laminopathies_logoZF BioLabs collaborated as a partner in an European Research Project on laminophaties, using the Zebrafish as an animal model to study in vivo the molecular mechanisms of the disease pathology.

Ageing

Comunidad de Madrid_LogoNew screening R&D searching for anti-ageing compounds based on zebrafish embryos. We developed a method to induce senescence associated to oxidative stress in zebrafish embryos.

We studied the senescent level by measuring the biochemical marker SA-beta-galactosidose. We also performed analysis of genetic markers related to ageing processes. Funded by Comunidad de Madrid

ALTERNATIVE TESTING METHODS

Euroecotox

Eutocotox_logo

ZF BioLabs was the Coordinator of an European project that lead to an European Network for alternative testing strategies in ecotoxicology; EUROECOTOX under the Seven Framework Program (FP7).

R&D for Biological and Technological Advancements in Ecotoxicology

Canal de Isabel II_logoTogether with a large water supply company (Canal de Isabel II) ZF BioLabs developed the technology  Fast acute Toxicity Test with ZebrafIsh that is very useful to detect toxicity of different compounds in a very short period of time. Funded by Comunidad de Madrid

Development of Acute Toxicity Test

During this R&D  project, ZF Biolabs developed a new alternative Comunidad de Madrid_Logomethod based on Zebrafish embryos to evaluate acute toxicity and toxicogenomics of new drugs. Funded by Comunidad de Madrid

Evaluating in vivo toxicity of nanomaterials

Instituto de Ciencia de los materiales de Aragón_Logo

It is important for nanomaterials R&D projects to include toxicological and safety evaluation so that actual risks of nanomaterials are defined and adverse environmental consequences are minimized. In collaboration with the Institute of Materials Science of Aragon (ICMA), ZF Biolabs has participated in the evaluation of different nanomaterials.

New alternative method to evaluate cardiotoxicity of compounds Instituto madrileño del desarrollo_logo

ZF Biolabs developed the ZF S-Cardiac kit to identify potential cardiotoxic effects of drugs based in the Zebrafish embryo model. Funded by Comunidad de Madrid.

Determination of bioconcentration in ecotoxicity bioassay included in the REACH normative

Instituto de quimica orgánica general_logoUCM_logoThis project was a Cooperation Project with the Analytical Chemical Department of Complutense University of Madrid and the Instrumental Analysis and Environmental Chemistry Department (CSIC’s Institute of General Organic Chemistry). The main aim of the project was to develop a method for determination of the bioconcentration factor using Zebrafish embryos that serves as an alternative to the adult fish bioassay 305 of OECD. Funded by the agriculture, food and environment ministry.

R&D for a novel developmental toxicity assayConsejeria de Economía e Innovación Tecnológica Dirección General de Innovación Tecnológica_logo

During this R&D project ZF BioLabs created a developmental toxicity test using Zebrafish embryos as an alternative to the mammalian model and with the very deep knowledge of the Zebrafish embryology adquired, an Atlas of Malformations was compiled. Funded by Comunidad de Madrid.

COSMETIC INDUSTRY

R&D of new natural products with photo-protective properties

Industrial Farmaceutica Cantabria_logoIn this project ZF BioLabs worked as CRO with a large Spanish Pharmaceutical company (Industrial Farmaceutica Cantabria S.A.) testing new cosmetic compounds against the damage caused by ultraviolet radiation. It was developed a screening system for zebrafish embryos to detect the photoprotective activity of natural extracts from seaweed.

SYSTEM BIOLOGY

New vertebrate model for ageing and Systems Biology

ZF Biolabs developed a new vertebrate model for ageing and Systems Biology approach, a  mathematical model of relevant age-dependant biological processes (growth, reproduction and mortality) in zebrafish. This knowledge could be applied to develop a Quantitative System Toxicology (QST) platform, taking advantage of zebrafish as a toxicology animal model.Leopoldina_logo
The work was presented at the “International Symposium on “Developmental origins of health and disease” held in Greifswald (Germany) on September 4th and 5th 2009, organized by the German National Academy of Sciences “Leopoldina”.